反应详情

80 mg (0.26 mmol) of 3-[(5,6-difluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]pentane-2,4-dione are dissolved with 40.4 mg (0.26 mmol) of cyclobutyl 3-aminocrotonate in 2 ml of 2-propanol and heated under reflux under argon for 12 h. The solvent is removed in vacuo, and the residue is purified by column chromatography (mobile phase: ethyl acetate/cyclohexane 1:2). 31.0 mg (27% of theory) of the title compound are obtained as a yellow solid.

1. temperatureheated
2. temperatureunder reflux under argon for 12 h
3. customThe solvent is removed in vacuo
4. customthe residue is purified by column chromatography (mobile phase: ethyl acetate/cyclohexane 1:2)