反应详情

40 mg (0.18 mmol) of 5-chloro-2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 31 mg (0.18 mmol) of 2,4-pentanedione, 25 mg (0.18 mmol) of n-propyl 3-aminocrotonate and 11 mg (0.18 mmol) of acetic acid in 2 ml of 2-propanol and heated under reflux under argon for 10 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 33 mg (42% of theory) of the title compound are obtained as a yellow solid.

1. temperatureheated
2. temperatureunder reflux under argon for 10 h
3. customThe solvent is removed in vacuo
4. customthe residue is purified by preparative HPLC