反应详情

230 mg (0.63 mmol) of 1-(4-methoxyphenyl)-2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-butane-1,3-dione are heated with 81.9 mg (0.63 mmol) of ethyl 3-aminocrotonate in 5 ml of 2-propanol under reflux overnight. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 50 mg (16% of theory) of the title compound are obtained.

1. temperatureunder reflux overnight
2. customThe solvent is removed in vacuo
3. customthe residue is purified by preparative HPLC