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HRID1669784

反应详情

EQUATION

反应方程式

HRID 1669784 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)/C=C(/C)N
HCID643756

未命名化合物

结构：COc1cccc(C(=O)C(=Cc2cccc3c(=O)cc(C)oc23)C(C)=O)c1
HCID67342989

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(C)NC(C)=C(C(=O)c2cccc(OC)c2)C1c1cccc2c(=O)cc(C)oc12
HCID57503343

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

245 mg (0.67 mmol) of 1-(3-methoxyphenyl)-2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-butane-1,3-dione are heated with 87 mg (0.67 mmol) of ethyl 3-aminocrotonate in 5 ml of 2-propanol under reflux overnight. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 102 mg (32% of theory) of the title compound are obtained.

WORKUP

后处理

  1. temperatureunder reflux overnight
  2. customThe solvent is removed in vacuo
  3. customthe residue is purified by preparative HPLC