Propyl 3-aminobut-2-enoate → n-Propyl 5-(2-methoxybenzoyl)-2,6-dimethyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydro-pyridine-3-carboxylate

HRID 1669787Notes

Reaction equation

HRID 1669787 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:27])[C:10](=[CH:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:24]=1[O:23][C:22]([CH3:25])=[CH:21][C:20]2=[O:26])[C:11](=O)[CH3:12].[NH2:28]/[C:29](/[CH3:37])=[CH:30]\[C:31]([O:33][CH2:34][CH2:35][CH3:36])=[O:32]>CC(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:10]1[CH:14]([C:15]2[CH:16]=[CH:17][CH:18]=[C:19]3[C:24]=2[O:23][C:22]([CH3:25])=[CH:21][C:20]3=[O:26])[C:30]([C:31]([O:33][CH2:34][CH2:35][CH3:36])=[O:32])=[C:29]([CH3:37])[NH:28][C:11]=1[CH3:12])=[O:27]

Participants

4

Reactant 2

HCID 12706963Propyl 3-aminobut-2-enoateHCID 673435071-(2-Methoxyphenyl)-2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]butane-1,3-dione

Product 1

HCID 57503346n-Propyl 5-(2-methoxybenzoyl)-2,6-dimethyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydro-pyridine-3-carboxylate

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

240 mg (0.62 mmol) of 1-(2-methoxyphenyl)-2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-butane-1,3-dione are heated with 94 mg (0.62 mmol) of n-propyl 3-aminocrotonate in 5 ml of 2-propanol under reflux overnight. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 108 mg (33% of theory) of the title compound are obtained.

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent is removed in vacuo
  3. customthe residue is purified by preparative HPLC

Sources & evidence

ORD record
ord-fe2e3d5eda6d43639611a1d1aa84eeb2
Source dataset
uspto-grants-2011_08
Patent number
US07989633B2

Reaction notes

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