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HRID1669787

反应详情

EQUATION

反应方程式

HRID 1669787 的结构方程式

REACTANTS

反应物

2
结构：CCCOC(=O)/C=C(/C)N
HCID12706963

未命名化合物

结构：COc1ccccc1C(=O)C(=Cc1cccc2c(=O)cc(C)oc12)C(C)=O
HCID67343507

未命名化合物

PRODUCTS

生成物

1
结构：CCCOC(=O)C1=C(C)NC(C)=C(C(=O)c2ccccc2OC)C1c1cccc2c(=O)cc(C)oc12
HCID57503346

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

240 mg (0.62 mmol) of 1-(2-methoxyphenyl)-2-[(2-methyl-4-oxo-4H-chromen-8-yl)methylene]-butane-1,3-dione are heated with 94 mg (0.62 mmol) of n-propyl 3-aminocrotonate in 5 ml of 2-propanol under reflux overnight. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 108 mg (33% of theory) of the title compound are obtained.

WORKUP

后处理

  1. temperatureunder reflux overnight
  2. customThe solvent is removed in vacuo
  3. customthe residue is purified by preparative HPLC