反应详情

848 mg (4.50 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 523 mg (4.50 mmol) of methyl 3-oxobutanoate, 790 mg (4.50 mmol) of 3-amino-1-(4-methylphenyl)but-2-en-1-one and 387 μl (6.72 mmol) of acetic acid in 10 ml of 2-propanol and heated under reflux under argon for 30 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 961 mg (44% of theory) of the title compound are obtained as a yellow solid.

1. temperatureheated
2. temperatureunder reflux under argon for 30 h
3. customThe solvent is removed in vacuo
4. customthe residue is purified by preparative HPLC