5-(4-Fluorophenyl)-3-methyl-1,2-oxazole → HCID 67342452, compound

HRID 1669806Notes

Reaction equation

HRID 1669806 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[O:4][N:3]=1.[H][H]>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=1)=[O:4]

Participants

5

Reactant 2

HCID 125395405-(4-Fluorophenyl)-3-methyl-1,2-oxazoleHCID 178418361HCID 178418361, compound

Product 1

HCID 67342452HCID 67342452, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

3-Methyl-5-(4-fluorophenyl)isoxazole (620 mg, 3.49 mmol) is introduced into 16 ml of ethanol, platinum(IV) oxide catalyst (62 mg) is added, and the mixture is then hydrogenated under atmospheric pressure hydrogen for 12 h. The catalyst is filtered off and the filtrate is concentrated. 573 mg (91% of theory) of the title compound are obtained as a white solid.

Workup

  1. additionis added
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-bc8c514d17cf4445b9a84141324b1a31
Source dataset
uspto-grants-2011_08
Patent number
US07989633B2

Reaction notes

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