Lithium Hydroxide → 3-Methoxy-2,2-dimethylpropanoic acid

HRID 1670003Notes

Reaction equation

HRID 1670003 reaction equation
C([O:3][C:4](=[O:11])[C:5]([CH3:10])([CH3:9])[CH2:6][O:7][CH3:8])C.[Li+].[OH-]>CO>[CH3:9][C:5]([CH3:10])([CH2:6][O:7][CH3:8])[C:4]([OH:11])=[O:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 14459623HCID 14459623, compound

Product 1

HCID 30175063-Methoxy-2,2-dimethylpropanoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2,2-dimethyl-3-methoxypropionic acid ethyl ester (1.17 g, 8.00 mmol) in an aqueous MeOH solution (MeOH/H2O=1/1, 24 mL) was added LiOH (560 mg, 16.0 mmol) at rt. After the rection mixture was stirred for 30 min., the solvent was removed in vacuo, and the residue was diluted with 1N HCl and EtOAc. The organic layer extracted with EtOAc, and the organic extracts were dried over MgSO4, filtered, and concentrated in vacuo. The crude product was used without further purification.

Workup

  1. customthe solvent was removed in vacuo
  2. additionthe residue was diluted with 1N HCl and EtOAc
  3. extractionThe organic layer extracted with EtOAc
  4. dry with materialthe organic extracts were dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe crude product was used without further purification

Sources & evidence

ORD record
ord-51243d9969e54a98931f1cf069cbbb4a
Source dataset
uspto-grants-2011_08
Patent number
US07989634B2

Reaction notes

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