Oxalyl chloride → 2,2-Dimethyl-3-acetyloxypropionyl chloride

HRID 1670007Notes

Reaction equation

HRID 1670007 reaction equation
[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:15])=O>C1C=CC=CC=1>[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3]([Cl:15])=[O:4]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 131926213-(Acetyloxy)-2,2-dimethylpropanoic acid

Product 1

HCID 111946632,2-Dimethyl-3-acetyloxypropionyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
0 °C

Procedure

Intermediate 73, 2,2-dimethyl-3-acetyloxypropionic acid (11.76 g, 80 mmol) was dissolved in benzene (100 mL), and the reaction solution was cooled to 0° C. Oxalyl chloride (15.0 g, 120 mmol) was added dropwise. After being stirred for 3 h, the solvent was removed in vacuo, and the residue was distilled in vacuo to give the title compound.

Workup

  1. customthe solvent was removed in vacuo
  2. distillationthe residue was distilled in vacuo

Sources & evidence

ORD record
ord-d18dfe5a8ff5485684c215111b335228
Source dataset
uspto-grants-2011_08
Patent number
US07989634B2

Reaction notes

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