反应详情

To a solution of methyl 2,3-dibromopropionate (92.50 g, 10.0 mmol) and K2CO3 (4.10 g 30.0 mmol) in acetonitrile (30 mL) was added dropwise benzylamine (1.20 mL, 11 mmol). After being stirred at rt for 4 h, and the reaction mixture was quenched with a saturated aqueous NH4Cl solution. The organic material was extracted with EtOAc, the extracts dried over MgSO4, concentrated in vacuo. The residue was purified by column chomatography (EtOAc/Hex 2/1) to give the title compound (1.62 g, 85%).

1. customthe reaction mixture was quenched with a saturated aqueous NH4Cl solution
2. extractionThe organic material was extracted with EtOAc
3. dry with materialthe extracts dried over MgSO4
4. concentrationconcentrated in vacuo
5. customThe residue was purified by column chomatography (EtOAc/Hex 2/1)