N-cyclohexylpiperidin-4-amine → (2R)-2-(BOC)amino-N-[4-(cyclohexylamino)piperidine-1-yl]-3-(4-chlorophenyl)propionamide

HRID 1670025Notes

Reaction equation

HRID 1670025 reaction equation
C1([N:7](C(=O)CNC(OC(C)(C)C)=O)[C@H]2CCNC2)CCCCC1.[C:24]([NH:31][C@H:32]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][CH:38]=1)[C:33]([OH:35])=O)([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25].[CH:44]1([NH:50][CH:51]2[CH2:56][CH2:55][NH:54][CH2:53][CH2:52]2)[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]1>>[C:24]([NH:31][C@H:32]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][CH:38]=1)[C:33]([NH:7][N:54]1[CH2:53][CH2:52][CH:51]([NH:50][CH:44]2[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]2)[CH2:56][CH2:55]1)=[O:35])([O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:25]

Participants

4

Reactant 3

HCID 4778242N-cyclohexylpiperidin-4-amineHCID 7018791N-Boc-4-chloro-D-phenylalanineHCID 67343482(3S)-3-{cyclohexyl[(N-BOC)aminoacetyl]amino}pyrrolidine

Product 1

HCID 67345059(2R)-2-(BOC)amino-N-[4-(cyclohexylamino)piperidine-1-yl]-3-(4-chlorophenyl)propionamide

Procedure

The title compound was prepared following the procedure described in Intermediate 129 using (2R)-2-(BOC)amino-3-(4-chlorophenyl)propionic acid and 4-[(cyclohexyl)amino]piperidine.

Sources & evidence

ORD record
ord-9f15c565369e48e2a12b52c72d969ff7
Source dataset
uspto-grants-2011_08
Patent number
US07989634B2

Reaction notes

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