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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1670032Generated: November 1, 2026

(2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamide → (2R)-2-(BOC)amino-N-{3-[cyclohexyl(isobutyryl)amino]azetidine-1-yl}-3-(4-chlorophenyl)propionamide

https://huagongshe.com/reaction/1670032

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamideHCID 67342965—
Reactant(3S)-3-[cyclohexyl(isobutyryl)amino]pyrrolidineHCID 67345620—
SolventIsobutyryl chlorideHCID 62325—
Product(2R)-2-(BOC)amino-N-{3-[cyclohexyl(isobutyryl)amino]azetidine-1-yl}-3-(4-chlorophenyl)propionamideHCID 67344982—

Reaction Steps

The title compound was prepared following the procedure described in Step A of Intermediate 36 using (2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamide prepared in Intermediate 202 and isobutyrylchloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07989634B2
Source datasetuspto-grants-2011_08
ORD IDord-c7369021f13f4028b1834f708d449d60
Source noteuspto-grants-2011_08