HRID1670032

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)NN1CC(NC2CCCCC2)C1

HCID67342965

未命名化合物

2 次

HCID67345620

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(=O)N(C1CCCCC1)C1CN(NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)OC(C)(C)C)C1

HCID67344982

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID62325

2-Methylpropanoyl chloride

C4H7ClO

PROCEDURE

实验过程

The title compound was prepared following the procedure described in Step A of Intermediate 36 using (2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamide prepared in Intermediate 202 and isobutyrylchloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c7369021f13f4028b1834f708d449d60
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989634B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH:1]1([N:7]([C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[C@H:8]2[CH2:12]C[NH:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:18]([NH:25][C@H:26]([CH2:41][C:42]1[CH:47]=[CH:46][C:45]([Cl:48])=[CH:44][CH:43]=1)[C:27]([NH:29]N1CC(NC2CCCCC2)C1)=[O:28])([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>C(Cl)(=O)C(C)C>[C:18]([NH:25][C@H:26]([CH2:41][C:42]1[CH:47]=[CH:46][C:45]([Cl:48])=[CH:44][CH:43]=1)[C:27]([NH:29][N:10]1[CH2:9][CH:8]([N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:13](=[O:17])[CH:14]([CH3:15])[CH3:16])[CH2:12]1)=[O:28])([O:20][C:21]([CH3:23])([CH3:24])[CH3:22])=[O:19]