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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1670033Generated: October 31, 2026

Methyl bromoacetate → (2R)-2-(BOC)amino-N-{3-[cyclohexyl(methoxycarbonyl)amino]azetidine-1-yl}-3-(4-chlorophenyl)propionamide

https://huagongshe.com/reaction/1670033

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl bromoacetateHCID 60984—
Reactant(2R)-N-methanesulfonyl-(4-chlorophenyl)alanineHCID 967528—
Reactant(2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamideHCID 67342965—
Product(2R)-2-(BOC)amino-N-{3-[cyclohexyl(methoxycarbonyl)amino]azetidine-1-yl}-3-(4-chlorophenyl)propionamideHCID 67344148—

Reaction Steps

The title compound was prepared following the procedure described in Step A of Intermediate 135 using (2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamide prepared in Intermediate 202 and methyl bromoacetate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07989634B2
Source datasetuspto-grants-2011_08
ORD IDord-e88700549a0548c1b65a1ce912b3f602
Source noteuspto-grants-2011_08