HRID1670033

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID60984

Methyl bromoacetate

C3H5BrO2

结构：C[C@H](C(=O)O)N(c1ccc(Cl)cc1)S(C)(=O)=O

HCID967528

未命名化合物

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)NN1CC(NC2CCCCC2)C1

HCID67342965

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)N(C1CCCCC1)C1CN(NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)OC(C)(C)C)C1

HCID67344148

未命名化合物

PROCEDURE

实验过程

The title compound was prepared following the procedure described in Step A of Intermediate 135 using (2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamide prepared in Intermediate 202 and methyl bromoacetate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e88700549a0548c1b65a1ce912b3f602
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989634B2
来源说明: uspto-grants-2011_08

反应 SMILES

CS(N(C1C=CC(Cl)=CC=1)[C@@H](C(O)=O)C)(=O)=O.[C:18]([NH:25][C@H:26]([CH2:41][C:42]1[CH:47]=[CH:46][C:45]([Cl:48])=[CH:44][CH:43]=1)[C:27]([NH:29][N:30]1[CH2:33][CH:32]([NH:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)[CH2:31]1)=[O:28])([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19].BrC[C:51]([O:53][CH3:54])=[O:52]>>[C:18]([NH:25][C@H:26]([CH2:41][C:42]1[CH:43]=[CH:44][C:45]([Cl:48])=[CH:46][CH:47]=1)[C:27]([NH:29][N:30]1[CH2:31][CH:32]([N:34]([CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)[C:51]([O:53][CH3:54])=[O:52])[CH2:33]1)=[O:28])([O:20][C:21]([CH3:23])([CH3:24])[CH3:22])=[O:19]