3-Fluorophenylboronic acid → 5-Benzyloxy-3'-fluoro-biphenyl-3-carboxylic Acid Methyl Ester
Reaction equation
[CH3:1][O:2][C:3](=[O:27])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[C:6]([C:18]2[CH:26]=[CH:25][C:21]3OCO[C:20]=3[CH:19]=2)[CH:5]=1.COC(=O)C1C=C(OS(C(F)(F)[F:42])(=O)=O)C=C(OCC2C=CC=CC=2)C=1.FC1C=C(B(O)O)C=CC=1>>[CH3:1][O:2][C:3]([C:4]1[CH:5]=[C:6]([C:18]2[CH:26]=[CH:25][CH:21]=[C:20]([F:42])[CH:19]=2)[CH:7]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:9]=1)=[O:27]Participants
4
Procedure
The title compound was prepared in the same way as 3-benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic acid methyl ester (described in Method B, step 3) from 3-benzyloxy-5-trifluoromethanesulfonyloxy-benzoic acid methyl ester and 3-fluorophenylboronic acid.
Sources & evidence
- ORD record
- ord-9c7f6455e9a1476d9c6d3f9512d5ec47
- Source dataset
- uspto-grants-2011_08
- Patent number
- US07989454B2
Reaction notes
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