Diisopropylethylamine → HCID 67337985, compound
Reaction equation
[CH2:1]([O:3][C:4](=[O:41])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28](=[O:32])[N:29]([CH3:31])[CH3:30])[CH:25]=[C:24]([Br:33])[CH:23]=2)[C:10]=1[CH2:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH3:2].BrC1C=C(C=C(OCCCCCCC2C=CC=C(OCCCC(OCC)=O)C=2CCC(OCC)=O)C=1)C(O)=O.C1CN([P+](Br)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.Cl.[F:106][C:107]1([F:112])CCN[CH2:108]1.CCN(C(C)C)C(C)C>ClCCl>[CH2:1]([O:3][C:4](=[O:41])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]([N:29]3[CH2:30][CH2:108][C:107]([F:112])([F:106])[CH2:31]3)=[O:32])[CH:25]=[C:24]([Br:33])[CH:23]=2)[C:10]=1[CH2:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH3:2]Participants
7
Procedure
The title compound was prepared by the same method as 4-{3-[6-(3-bromo-5-dimethylcarbamoyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester starting from 3-bromo-5-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-benzoic acid (550 mg, 0.905 mmol), PyBroP (508 mg, 1.09 mmol), 3,3-difluoropyrrolidine hydrochloride salt (156 mg, 1.09 mmol) and DIPEA (473 uL, 2.72 mmol) in dichloromethane (15 mL) to obtain 4-[3-{6-[3-bromo-5-(3,3-difluoro-pyrrolidine-1-carbonyl)-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (580 mg, 92%) as a colorless oil.
Sources & evidence
- ORD record
- ord-23f12e345cc44ce39341e72e917c0df9
- Source dataset
- uspto-grants-2011_08
- Patent number
- US07989454B2
Reaction notes
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