HCID 57905822, compound → HCID 57905813, compound

HRID 1670156Notes

Reaction equation

HRID 1670156 reaction equation
[C:1]([CH2:4][CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]#[C:25][C:26]2[CH:27]=[C:28]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH:29]=[C:30]([C:32]([N:34]3[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]3)=[O:33])[CH:31]=2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([OH:3])=[O:2]>CO.[Pd]>[C:1]([CH2:4][CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]2[CH:27]=[C:28]([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH:29]=[C:30]([C:32]([N:34]3[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]3)=[O:33])[CH:31]=2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([OH:3])=[O:2]

Participants

4

Reactant 1

HCID 57905822HCID 57905822, compound

Product 1

HCID 57905813HCID 57905813, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 4-(2-(2-Carboxy-ethyl)-3-{7-[5-(4-methyl-piperazine-1-carbonyl)-biphenyl-3-yl]-hept-6-ynyl}-phenoxy)-butyric acid (20 mg, 0.032 mmol) in MeOH (4 mL) was added 10% Pd/C (2 mg). The mixture was stirred for 4 h under hydrogen atmosphere at room temperature. The resulting suspension was filtered through Celite™ and concentrated under reduced pressure to afford the title compound. Yield: 90%

Workup

  1. filtrationThe resulting suspension was filtered through Celite™
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-602a58c8f3e44be997b6c1eee334548e
Source dataset
uspto-grants-2011_08
Patent number
US07989454B2

Reaction notes

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