反应详情

A solution of N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide (70 mg, 0.23 mmol) in 3 mL of MeOH was added 2 mL of 6 N HCl. The mixture was then heated at reflux for 48 h. After cooling down, the solvent was removed under reduced pressure and the residue was purified by solid extraction (Waters Oasis MCX extraction cartridge) to give 4-(4-amino-3-fluorophenoxy)pyridin-2-amine (27 mg, 54% yield). MS (ESI+): m/z 220.21 (M+H)+.

1. temperatureThe mixture was then heated
2. temperatureat reflux for 48 h
3. temperatureAfter cooling down
4. customthe solvent was removed under reduced pressure
5. customthe residue was purified by solid extraction (Waters Oasis MCX extraction cartridge)