反应详情

0.25 g of Compounds (14) was dissolved in 20 ml of acetic acid. While stirring, 0.44 g of 30% hydrogen peroxide solution, and 0.04 g of sodium tungstate dihydrate were added sequentially. The mixture was stirred at room temperature for 12 hours, then poured into water, and extracted with ethyl acetate. The organic layer was washed with saturated sodium hydrogencarbonate, dried over magnesium sulfate, and then filtered. The filtrate was concentrated under reduced pressure to produce 0.29 g of 5-methanesulfonyl-1-methyl-3-(trifluoromethyl)pyrazole (2-1).

1. stirringThe mixture was stirred at room temperature for 12 hours
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with saturated sodium hydrogencarbonate
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. concentrationThe filtrate was concentrated under reduced pressure