HCID 15986279, compound → HCID 15986353, compound

HRID 1670403Notes

Reaction equation

HRID 1670403 reaction equation
[CH:1]([C:3]1[N:18]=[N:17][C:6]2[NH:7][C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[NH:10][C:11](=[O:12])[C:5]=2[CH:4]=1)=[CH2:2].[H][H]>[Pd].CO>[CH2:1]([C:3]1[N:18]=[N:17][C:6]2[NH:7][C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[NH:10][C:11](=[O:12])[C:5]=2[CH:4]=1)[CH3:2]

Participants

5

Reactant 2

HCID 15986279HCID 15986279, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15986353HCID 15986353, compoundYield 100.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-vinyl-5,10-dihydro-3,4,5,10-tetraaza-dibenzo[a,d]cyclohepten-11-one from Example 10 (40 mg, 0.17 mmol) and 5 mg of palladium on charcoal (10%) in 50 ml of methanol was stirred under 1 atm of hydrogen for 70 min. Filtration and evaporation to dryness afforded the title compound as a pale yellow solid (41 mg, 87%).

Workup

  1. filtrationFiltration and evaporation to dryness

Sources & evidence

ORD record
ord-f95200d4c2f14bf1a155fec1bc71e50f
Source dataset
uspto-grants-2011_08
Patent number
US07994160B2

Reaction notes

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