Hydrochloric Acid → (3S)-3-amino-7-phenyl-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one hydrochloride

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Reaction Steps

5.63 g of 13a (15.97 mmol) are taken up in a 250 ml round-bottomed flask and 140 ml of a solution of hydrochloric acid in dioxane (4M) are added. The medium is stirred for 4 h at AT under argon. A precipitate forms and is filter-dried and washed with 5 ml of dioxane and then 5 ml of isopropyl ether. After drying, 5.7 g of amine 14a in hydrochloride form are obtained.

Provenance & Evidence