反应详情

5.63 g of 13a (15.97 mmol) are taken up in a 250 ml round-bottomed flask and 140 ml of a solution of hydrochloric acid in dioxane (4M) are added. The medium is stirred for 4 h at AT under argon. A precipitate forms and is filter-dried and washed with 5 ml of dioxane and then 5 ml of isopropyl ether. After drying, 5.7 g of amine 14a in hydrochloride form are obtained.

1. customA precipitate forms and is filter-dried
2. washwashed with 5 ml of dioxane
3. customAfter drying