Hydrochloric Acid → HCID 67327839, compound

HRID 1670424Notes

Reaction equation

HRID 1670424 reaction equation
[CH2:1]([N:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH2:6][C@H:5]([NH:14]C(=O)OC(C)(C)C)[C:4]1=[O:22])[CH3:2].[ClH:23]>O1CCOCC1>[ClH:23].[NH2:14][C@@H:5]1[C:4](=[O:22])[N:3]([CH2:1][CH3:2])[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57617719HCID 57617719, compound

Product 1

HCID 67327839HCID 67327839, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.286 g of 19 (0.934 mmol) is taken up in a 50 mL round-bottomed flask and 7 mL of dioxane and 7 mL of a solution of hydrochloric acid in dioxane (4M) are added. The medium is stirred overnight at RT under argon. After evaporation of the solvent, the residue is taken up in 1 mL of CH2Cl2 and 10 mL of isopropyl ether. The solid formed is drained and dried under vacuum. 185 mg of expected product 20 (white solid) are thus recovered.

Workup

  1. customAfter evaporation of the solvent
  2. customThe solid formed
  3. customdried under vacuum
  4. custom185 mg of expected product 20 (white solid) are thus recovered

Sources & evidence

ORD record
ord-3845f63394494e7e90219d87e2163346
Source dataset
uspto-grants-2011_08
Patent number
US07994161B2

Reaction notes

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