HCID 57617718, compound → HCID 57617755, compound

HRID 1670426Notes

Reaction equation

HRID 1670426 reaction equation
[CH2:1]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[O:8][CH2:7][C@H:6]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:5]1=[O:23])[CH:2]=[CH2:3]>[Pd].CO>[O:23]=[C:5]1[N:4]([CH2:1][CH2:2][CH3:3])[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[O:8][CH2:7][C@@H:6]1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 1

HCID 57617718HCID 57617718, compound

Product 1

HCID 57617755HCID 57617755, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In an autoclave containing 270 mg of 21 (0.848 mmol), 20 mg of Pd/C (10%) and 5 mL of MeOH, hydrogenation is performed at 4 bar for 16 h at 20° C. After filtration of the catalyst on celite and evaporation of the solvent, 257 mg of expected product 23 are obtained, which product is used directly for the next stage.

Workup

  1. filtrationAfter filtration of the catalyst
  2. customon celite and evaporation of the solvent, 257 mg of expected product 23
  3. customare obtained

Sources & evidence

ORD record
ord-477c4449e450407a80b5cbc9f3d4c70c
Source dataset
uspto-grants-2011_08
Patent number
US07994161B2

Reaction notes

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