Iodoethane → HCID 11978438, compound

HRID 1670479Notes

Reaction equation

HRID 1670479 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[NH:12][C:13](=[O:26])[N:14]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([CH3:25])([CH3:24])[C:22]#[N:23])=[CH:17][CH:16]=4)[C:5]=3[C:4]=2[CH:3]=1.I[CH2:28][CH3:29].[N:30]1[CH:35]=[CH:34][CH:33]=[C:32](B(O)O)[CH:31]=1>>[CH2:28]([N:12]1[C:6]2[CH:7]=[N:8][C:9]3[CH:10]=[CH:11][C:2]([C:32]4[CH:31]=[N:30][CH:35]=[CH:34][CH:33]=4)=[CH:3][C:4]=3[C:5]=2[N:14]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([CH3:25])([CH3:24])[C:22]#[N:23])=[CH:19][CH:20]=2)[C:13]1=[O:26])[CH3:29]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 27343783-Pyridinylboronic acidHCID 426095694-(8-Bromo-2,3-dihydro-2-oxo-1H-imidazo(4,5-c)quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile

Product 1

HCID 11978438HCID 11978438, compound

Procedure

The title compound is prepared in a similar manner as described in Example 1 by reacting 2-[4-(8-bromo-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-2-methyl-propionitrile (Example 1h) with iodoethane (Fluka, Buchs, Switzerland) and using 3-pyridineboronic acid. ES-MS: 434 (M+H)+; analytical HPLC: tret=2.55 min (Grad 1).

Workup

  1. customtret=2.55 min (Grad 1)

Sources & evidence

ORD record
ord-fa175575c54d4cb09230ae2a939f2b2d
Source dataset
uspto-grants-2011_08
Patent number
US07994170B2

Reaction notes

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