Pyrazole → 4-(1H-Pyrazol-1-yl)aniline

HRID 1670483Notes

Reaction equation

HRID 1670483 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[CH:14][CH:13]=[N:12]1>>[N:11]1([C:2]2[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=2)[CH:15]=[CH:14][CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 9590p-Fluoronitrobenzene

Product 1

HCID 5942744-(1H-Pyrazol-1-yl)aniline

Procedure

The title compound is obtained as described in Example 18a/b using 1-fluoro-4-nitro-benzene (Fluka, Buchs; Switzerland) and 1H-Pyrazole (Fluka, Buchs, Switzerland). Title compound: ES-MS: 160.2 (M+H)+; analytical HPLC: tret=3.61 minutes (Grad 2).

Sources & evidence

ORD record
ord-b75a0f973a884557bc8983b9b58f7942
Source dataset
uspto-grants-2011_08
Patent number
US07994170B2

Reaction notes

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