反应详情

温度

100 °C

100 mg (0.198 mmol) of 2-[4-(4-chloro-3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-2-methyl-propionitrile (Example 109b), 27 mg (0.278 mmol) sodium tert-butanolate, 11 mg (0.02 mmol) SK-CC01-A catalyst and 33 mg (0.238 mmol) 4-methoxybenzylamine in 0.4 ml degassed toluene under argon are heated at 100° C. for 22 h. The reaction mixture is quenched with sat. aqueous NaHCO3 and extracted with CH2Cl2 (2×). The organic layers are washed with sat. aqueous NaHCO3, dried over Na2SO4, filtered and evaporated to provide the title compound as a crude brown solid. ES-MS: 605 (M+H)+; analytical HPLC: tret=3.29 minutes (Grad 1).

1. customThe reaction mixture is quenched with sat. aqueous NaHCO3
2. extractionextracted with CH2Cl2 (2×)
3. washThe organic layers are washed with sat. aqueous NaHCO3
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated