Hydrochloric Acid → HCID 24771590, compound

HRID 1670690Notes

Reaction equation

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:19]3[N:20]4[CH:26]=[C:25]([C:27]([O:29]C)=[O:28])[CH:24]=[CH:23][C:21]4=[N:22][C:18]=3[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:31])=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:19]3[N:20]4[CH:26]=[C:25]([C:27]([OH:29])=[O:28])[CH:24]=[CH:23][C:21]4=[N:22][C:18]=3[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:31])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 24771031HCID 24771031, compound

Product 1

HCID 24771590HCID 24771590, compoundYield 91%

Conditions

Temperature: 60 °C

Procedure

A suspension of compound 11 (1.0 equiv., 0.060 mmol, 0.025 g) in a concentrated aqueous HCl solution (1 ml) was stirred at 60° C. overnight. The solvent was concentrated under reduced pressure to give the hydrochloride salt of 5,6-dihydro-6-(4-nitrophenyl)-5-oxo-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-9-carboxylic acid (71), which was further dried under high vacuum (0.024 g, yield=91%, purity (LC)=98%).

Workup

concentrationThe solvent was concentrated under reduced pressure

Sources & evidence

ORD record: ord-1724ed93ccbd4fb5b2be63672d6812bd
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07994187B2

Reaction notes

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