反应详情

温度

70 °C

A mixture of compound 13 (1.0 equiv., 0.22 mmol, 0.100 g) and methylamine (40% in water, 6 ml) in ethanol (8 ml) was heated at 70° C. for 4 h. After cooling, the reaction product was filtered off and washed with isopropanol and isopropylether successively to give N-methyl-2-[[5,6-dihydro-6-(4-nitrophenyl)-5-oxo-pyrido[2′,1′:2,3]imidazo-[4,5-c]isoquinolin-9-yl]oxy]-acetamide (15) (0.057 g, yield=58%, purity (LC)=98%) as a light yellow powder.

1. temperatureAfter cooling
2. filtrationthe reaction product was filtered off
3. washwashed with isopropanol and isopropylether successively