反应详情

A solution of compound 73 (0.327 mmol, 0.150 g) in concentrated aqueous HCl was stirred at room temperature overnight. The solvent was evaporated under vacuum and the crude reaction product was brought on a filter and washed with isopropanol and isopropylether successively to give the hydrochloride salt of 9-[2-hydroxy-ethoxy]-6-(4-nitrophenyl)-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one (74) (0.148 g, yield=100%, purity (LC)=95%).

1. customThe solvent was evaporated under vacuum
2. customthe crude reaction product
3. filtrationa filter
4. washwashed with isopropanol and isopropylether successively