HCID 24771592, compound → HCID 24771593, compound

HRID 1670712Notes

Reaction equation

HRID 1670712 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:19]3[N:20]4[CH:26]=[C:25]([O:27][CH2:28][CH2:29][O:30]C(=O)C)[CH:24]=[CH:23][C:21]4=[N:22][C:18]=3[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:34])=[CH:6][CH:5]=1)([O-:3])=[O:2]>Cl>[OH:30][CH2:29][CH2:28][O:27][C:25]1[CH:24]=[CH:23][C:21]2[N:20]([CH:26]=1)[C:19]1[N:10]([C:7]3[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[C:11](=[O:34])[C:12]3[C:17]([C:18]=1[N:22]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3

Participants

3

Reactant 1

HCID 24771592HCID 24771592, compound

Product 1

HCID 24771593HCID 24771593, compoundYield 108.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of compound 73 (0.327 mmol, 0.150 g) in concentrated aqueous HCl was stirred at room temperature overnight. The solvent was evaporated under vacuum and the crude reaction product was brought on a filter and washed with isopropanol and isopropylether successively to give the hydrochloride salt of 9-[2-hydroxy-ethoxy]-6-(4-nitrophenyl)-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one (74) (0.148 g, yield=100%, purity (LC)=95%).

Workup

  1. customThe solvent was evaporated under vacuum
  2. customthe crude reaction product
  3. filtrationa filter
  4. washwashed with isopropanol and isopropylether successively

Sources & evidence

ORD record
ord-fe7b172e71fa42ef95e5810e734f2cc5
Source dataset
uspto-grants-2011_08
Patent number
US07994187B2

Reaction notes

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