2-Aminothiazole → HCID 659850, compound

HRID 1670715Notes

Reaction equation

HRID 1670715 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[CH:7]([C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=[O:12])=O>C(O)C>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[NH:1][CH:7]1[C:9]2[C:10](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:11](=[O:13])[O:12]1

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 8406Phthalaldehydic acid

Product 1

HCID 659850HCID 659850, compoundYield 81.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Aminothiazole (I31) (1.0 equiv., 5.00 mmol, 0.500 g) and 2-formylbenzoic acid (I32) (1.2 equiv., 6.00 mmol, 0.900 g) were mixed in ethanol (8 ml) and heated at reflux for 2 h. Upon cooling, a precipitate was formed. The product was isolated by filtration and washed with isopropyl ether to afford 3-(2-thiazolylamino)-isobenzofuran-1(3H)-one (I33) (0.944 g, yield=81%).

Workup

  1. temperatureheated
  2. temperatureat reflux for 2 h
  3. temperatureUpon cooling
  4. customa precipitate was formed
  5. customThe product was isolated by filtration
  6. washwashed with isopropyl ether

Sources & evidence

ORD record
ord-1be90148b2cf4ef68368e0e94a43bee8
Source dataset
uspto-grants-2011_08
Patent number
US07994187B2

Reaction notes

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