反应详情

温度

60 °C

6-Oxo-1,4,5,6-tetrahydrobenzo[c]-1,7-naphthyridine-3(2H)-carboxylic acid tert-butyl ester (1.13 g) was added to tetrahydrofuran (30 ml) and dissolved by stirring the mixture at 60° C. 4N Hydrochloric acid-ethyl acetate (20 ml) was added, and the mixture was stirred with heating at 60° C. for 1 hr. The reaction mixture was ice-cooled, and the precipitated solid was collected by filtration, washed with ethyl acetate and dried to give 1,3,4,5-tetrahydrobenzo[c]-1,7-naphthyridin-6(2H)-one (884 mg, yield 90%).

1. dissolutiondissolved
2. stirringthe mixture was stirred
3. temperaturewith heating at 60° C. for 1 hr
4. temperaturecooled
5. filtrationthe precipitated solid was collected by filtration
6. washwashed with ethyl acetate
7. customdried