Hydrogen Bromide → 4-Bromo-2-(bromomethyl)-1-chlorobenzene

HRID 1670763Notes

Reaction equation

HRID 1670763 reaction equation
[BrH:1].[Br:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:11])=[C:7]([CH:10]=1)[CH2:8]O>>[Br:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:11])=[C:7]([CH:10]=1)[CH2:8][Br:1]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 5074766(5-Bromo-2-chlorophenyl)methanol

Product 1

HCID 115582804-Bromo-2-(bromomethyl)-1-chlorobenzene

Conditions

Temperature
70 °C

Procedure

An aqueous hydrobromide acid solution (2 M, 2 ml) was added to 5-bromo-2-chlorobenzyl alcohol (Aldrich Co., 1 g), and the mixture was stirred with heating at 70° C. for 1 hr. After completion of the reaction, the mixture was extracted three times with diethyl ether. The organic layer was dried and the solvent was evaporated under reduced pressure to give 5-bromo-2-chlorobenzylbromide (1.3 g).

Workup

  1. customAfter completion of the reaction
  2. extractionthe mixture was extracted three times with diethyl ether
  3. customThe organic layer was dried
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-2c2b466cc55d41178e9d48672fdaa181
Source dataset
uspto-grants-2011_08
Patent number
US07994196B2

Reaction notes

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