Water → HCID 11233071, compound

HRID 1670779Notes

Reaction equation

HRID 1670779 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([NH:10][C:11](=[O:15])OCC)=[N:2]1.[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.O>CN(C)C=O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([NH:10][C:11]([N:26]2[CH2:25][CH2:24][N:23]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[F:16])[CH2:28][CH2:27]2)=[O:15])=[N:2]1

Participants

5

Reactant 3

HCID 962WaterHCID 705291-(2-Fluorophenyl)piperazineHCID 12262771HCID 12262771, compound

Product 1

HCID 11233071HCID 11233071, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

Ethyl 1H-indazol-3-ylcarbamate (81 mg) and 1-(2-fluorophenyl)piperazine (Aldrich Co., 47 mg) were dissolved in dimethylformamide (2 ml), and the mixture was stirred with heating at 100° C. for 11 hr. After allowing to cool, water was added to the reaction mixture, and the precipitated solid was collected by filtration and dried to give 4-(2-fluorophenyl)-1-piperazinecarboxylic acid (1H-indazol-3-yl)amide (48 mg, yield 57%).

Workup

  1. temperatureto cool
  2. filtrationthe precipitated solid was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-c7feaf3a1bfe49b9ab77eec52f724b58
Source dataset
uspto-grants-2011_08
Patent number
US07994196B2

Reaction notes

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