反应详情

温度

50 °C

Purge a mixture of 3-cyano-2-piperidin-1-yl-propionic acid ethyl ester (2.36 g, 11.2 mmol) and PtO2 hydrate (0.400 g) in methanol (40 mL) with N2 and stir under 50 psi of H2 at 50° C. for 16 hours. Cool the reaction and filter through hyflo. Remove the solvent from the filtrate in vacuo to afford crude product and purify with a 0 to 10% methanol in CH2Cl2 gradient to afford 1.11 g (59%) of the titled product. Rf=0.18 (9/1 CH2Cl2/methanol). ES MS (m/z): 169 (M+).

1. customPurge
2. temperatureCool
3. customthe reaction
4. filtrationfilter through hyflo
5. customRemove the solvent from the filtrate in vacuo
6. customto afford crude product
7. custompurify with a 0 to 10% methanol in CH2Cl2 gradient