Water → HCID 57657996, compound

Participants

Reaction Steps

Treat a mixture of 3-[4-(tert-butyl-diphenyl-silanyloxy)-cyclohexyl]-1-[3,5-dichloro-4′-(4-trifluoromethyl-piperidine-1-carbonyl)-biphenyl-4-ylmethyl]-pyrrolidin-2-one (0.18 g), THF (6 mL) and water (6 mL) with TFA (2 mL) at room temperature for 1 hour and then at 55° C. for 12 hours. Cool the reaction, dilute with ethyl acetate, and wash with sodium bicarbonate (sat.). Dry the organic layer (Na2SO4), remove the solvent in vacuo to afford crude product, and purify on silica gel column with 50% ethyl acetate in hexanes to 100% ethyl acetate gradient to afford 0.075 g (59%) of the titled product. MS (m/z): 599 (M+).

Provenance & Evidence