反应详情

Treat a mixture of 3-[4-(tert-butyl-diphenyl-silanyloxy)-cyclohexyl]-1-[3,5-dichloro-4′-(4-trifluoromethyl-piperidine-1-carbonyl)-biphenyl-4-ylmethyl]-pyrrolidin-2-one (0.18 g), THF (6 mL) and water (6 mL) with TFA (2 mL) at room temperature for 1 hour and then at 55° C. for 12 hours. Cool the reaction, dilute with ethyl acetate, and wash with sodium bicarbonate (sat.). Dry the organic layer (Na2SO4), remove the solvent in vacuo to afford crude product, and purify on silica gel column with 50% ethyl acetate in hexanes to 100% ethyl acetate gradient to afford 0.075 g (59%) of the titled product. MS (m/z): 599 (M+).

1. additionTreat
2. temperatureCool
3. customthe reaction
4. washwash with sodium bicarbonate (sat.)
5. dry with materialDry the organic layer (Na2SO4)
6. customremove the solvent in vacuo
7. customto afford crude product
8. custompurify on silica gel column with 50% ethyl acetate in hexanes to 100% ethyl acetate gradient