Hydrochloric Acid → 2-(3-Phenyl-1h-indazol-1-yl)thiazole-4-carboxylic acid

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Reaction Steps

A 5 M aqueous solution of sodium hydroxide (10 mL, manufactured by Kanto Chemical Co., Inc.) was added to a solution of the compound of Example 1 (579 mg) in ethanol (10 mL, manufactured by Wako Pure Chemical Industries, Ltd.), and the mixture was stirred for 3 hours at room temperature. 5 M hydrochloric acid (10 mL, manufactured by Kanto Chemical Co., Inc.) was added to the mixture to neutralize the mixture, and then the mixture was extracted with ethyl acetate (3×10 mL), washed with brine (10 mL), and dried (MgSO4). The solvent was then evaporated, to give 477 mg of the title compound. LC-MS: HPLC retention time 5.31 minutes, m/z 322 (M+H), condition A-1.

Provenance & Evidence