反应详情

A 5 M aqueous solution of sodium hydroxide (10 mL, manufactured by Kanto Chemical Co., Inc.) was added to a solution of the compound of Example 1 (579 mg) in ethanol (10 mL, manufactured by Wako Pure Chemical Industries, Ltd.), and the mixture was stirred for 3 hours at room temperature. 5 M hydrochloric acid (10 mL, manufactured by Kanto Chemical Co., Inc.) was added to the mixture to neutralize the mixture, and then the mixture was extracted with ethyl acetate (3×10 mL), washed with brine (10 mL), and dried (MgSO4). The solvent was then evaporated, to give 477 mg of the title compound. LC-MS: HPLC retention time 5.31 minutes, m/z 322 (M+H), condition A-1.

1. extractionthe mixture was extracted with ethyl acetate (3×10 mL)
2. washwashed with brine (10 mL)
3. dry with materialdried (MgSO4)
4. customThe solvent was then evaporated