反应详情

To a suspension of 3-(2,4-dichloro-phenyl)-2,6-dimethyl-pyrazolo[5,1-b]oxazol-7-ylamine (Intermediate ID) (500 mg, 1.503 mmol) in DCM (10 ml) under N2 is added triethylamine (0.461 ml, 3.31 mmol) followed by propionyl chloride (0.144 ml, 1.654 mmol) at 0° C. After 2 hr, the reaction mixture is diluted with DCM (50 ml) and washed with 1M HCl, NaHCO3, Brine, dried (MgSO4) and evaporated down to give a pink solid. This is then triturated with Et2O to give the title compound as an off white solid. MS: n/z 351.9[M+H]+

1. washwashed with 1M HCl, NaHCO3, Brine
2. dry with materialdried (MgSO4)
3. customevaporated down
4. customto give a pink solid
5. customThis is then triturated with Et2O