HCID 67212729, compound → HCID 67212437, compound

HRID 1671310Notes

Reaction equation

HRID 1671310 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]2[N:17]=[C:16]([CH3:18])[C:15]([CH:19]([OH:23])[CH2:20][CH2:21][CH3:22])=[C:11]2[O:12][C:13]=1[CH3:14]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]2[N:17]=[C:16]([CH3:18])[C:15]([C:19](=[O:23])[CH2:20][CH2:21][CH3:22])=[C:11]2[O:12][C:13]=1[CH3:14]

Participants

4

Reactant 1

HCID 67212729HCID 67212729, compound

Product 1

HCID 67212437HCID 67212437, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
60 °C

Procedure

To a solution 1-[3-(2,4-dichloro-phenyl)-2,6-dimethyl-pyrazolo[5,1-b]oxazol-7-yl]-butan-1-ol (0.700 g, 1.982 mmol) in CHCl3 (15 ml) is added manganese dioxide (3.45 g, 39.6 mmol); the reaction mixture is heated to 60° C. for 18 hours and filtered through Celite® (filter material) 521, washing through with chloroform (75 ml). The solvent is removed in vacuo to yield the title compound as a white solid; MS: m/z 351.04 [M+H]+

Workup

  1. filtrationfiltered through Celite® (filter material) 521
  2. washwashing through with chloroform (75 ml)
  3. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-0d7a3358477c4b22a487f75253c754d0
Source dataset
uspto-grants-2011_08
Patent number
US07994203B2

Reaction notes

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