Imidazole → HCID 67212625, compound

HRID 1671313Notes

Reaction equation

HRID 1671313 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]3[N:16]=[C:15]([CH3:17])[C:14]([N:18]4[C:22]([CH3:23])=[N:21][C:20]([CH3:24])=[N:19]4)=[C:10]3[O:11][C:12]=2[CH3:13])=[C:4]([CH3:25])[CH:3]=1.COC1C2[C:32](=[C:33]3C(=CC=2)C(OC)=C[CH:35]=[N:34]3)[N:31]=CC=1.N1C=CN=C1.C([O-])([O-])=O.[Cs+].[Cs+]>CN1C(=O)CCC1>[N:31]1([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[N:9]4[N:16]=[C:15]([CH3:17])[C:14]([N:18]5[C:22]([CH3:23])=[N:21][C:20]([CH3:24])=[N:19]5)=[C:10]4[O:11][C:12]=3[CH3:13])=[C:4]([CH3:25])[CH:3]=2)[CH:32]=[CH:33][N:34]=[CH:35]1

Participants

6

Reactant 4

HCID 795ImidazoleHCID 10796Cesium carbonateHCID 104622984,7-Dimethoxy-1,10-phenanthrolineHCID 591860813-(4-Bromo-2-methylphenyl)-7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2,6-dimethylpyrazolo[5,1-b]oxazole

Product 1

HCID 67212625HCID 67212625, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
110 °C

Procedure

3-(4-Bromo-2-methylphenyl)-7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2,6-dimethyl pyrazolo[5,1-b]oxazole (Ex. 6.41) (40 mg, 0.100 mmol), 4,7-dimethoxy-1,10-phenanthroline (24.01 mg, 0.100 mmol), 1H-imidazole (8.16 mg, 0.120 mmol), Cu2O (0.715 mg, 5.00 μmol) and Cs2CO3 (45.6 mg, 0.140 mmol) are added to NMP (2 ml) and stirred at 110° C. for 5 days.

Sources & evidence

ORD record
ord-bc7da72c62cf40029d1947941721b3b5
Source dataset
uspto-grants-2011_08
Patent number
US07994203B2

Reaction notes

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