HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-4-Benzyl-2-(4-fluorophenyl)morpholine → (2S)-2-(4-fluorophenyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-4-Benzyl-2-(4-fluorophenyl)morpholine | HCID 12002488 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2S)-2-(4-fluorophenyl)morpholine | HCID 42182795 | 95.8% |
Reaction Steps
A suspension of (2S)-2-(4-fluorophenyl)-4-(benzyl)morpholine (250 mg) and 5% Pd—C (0.106 g) in ethanol (5 mL) was treated with hydrogen for 1 hr at 33-35° C. The suspension was filtered through celite and washed with ethanol. The solvent was evaporated to give (2S)-2-(4-fluorophenyl)morpholine (160 mg, 94%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994315B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-47e46a265d124a5f8e0b44af6e1ccb2c |
| Source note | uspto-grants-2011_08 |