Ethyl bromoacetate → HCID 43401322, compound

HRID 1671625Notes

Reaction equation

HRID 1671625 reaction equation
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[F:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[CH2:12][CH2:13][NH2:14]>CO>[F:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[CH2:12][CH2:13][NH:14][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 5339282-(3-Fluorophenyl)ethanamine

Product 1

HCID 43401322HCID 43401322, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl bromoacetate (0.166 g, 0.11 mL, 0.001 mol) and 3-fluorophenethylamine (0.139 g, 0.13 mL, 0.001 mol) were stirred in MeOH (10 mL) for 48 h. The solvent was removed in vacuo, and the residue was purified by column chromatography (silica gel, hexanes:EtOAc=2:3) to generate VIII-3 (0.083 g, 37%).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by column chromatography (silica gel, hexanes:EtOAc=2:3)

Sources & evidence

ORD record
ord-5fa875f6ef154138a2bb2694452085ab
Source dataset
uspto-grants-2011_08
Patent number
US07994326B2

Reaction notes

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