4-Fluorobenzaldehyde → 3-(3-Bromo-4-fluoro-phenyl)-3-chloro-2-oxo-propionic acid methyl ester

HRID 1671692Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([Cl:13])[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.[Br:16]C1C=C(C=CC=1F)C=O.FC1C=CC(C=O)=CC=1>>[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([Br:16])[CH:7]=1)[Cl:13]

Participants

Reactant 3

HCID 680234-Fluorobenzaldehyde

HCID 1736043-Bromo-4-fluorobenzaldehyde

HCID 57437156Methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate

Product 1

HCID 648978693-(3-Bromo-4-fluoro-phenyl)-3-chloro-2-oxo-propionic acid methyl ester

Procedure

This compound was synthesised as 3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester but using 3-bromo-4-fluorobenzaldehyde instead 4-fluorobenzaldehyde.

Sources & evidence

ORD record: ord-0fd2b62abc8440eba00f865aa61b3f91
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07994336B2

Reaction notes

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