2,4-Dimethylbenzaldehyde → Methyl β-chloro-2,4-dimethyl-α-oxobenzenepropanoate

HRID 1671696Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([Cl:13])C1C=CC(F)=CC=1.[CH3:16]C1C=C(C)C=CC=1C=O.F[C:27]1[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=1>>[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([Cl:13])[C:27]1[CH:34]=[CH:33][C:30]([CH3:31])=[CH:29][C:28]=1[CH3:16]

Participants

Reactant 3

HCID 618142,4-Dimethylbenzaldehyde

HCID 680234-Fluorobenzaldehyde

HCID 57437156Methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate

Product 1

HCID 64900672Methyl β-chloro-2,4-dimethyl-α-oxobenzenepropanoate

Procedure

This compound was synthesised as 3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester but using 2,4-dimethylbenzaldehyde instead 4-fluorobenzaldehyde.

Sources & evidence

ORD record: ord-0dd6b3b9fbbf4d0799a0a592090b8028
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07994336B2

Reaction notes

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