4-Fluorobenzaldehyde → 3-Chloro-3-(3,4-difluoro-phenyl)-2-oxo-propionic acid methyl ester

HRID 1671698Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([Cl:13])[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.[F:16]C1C=C(C=CC=1F)C=O.FC1C=CC(C=O)=CC=1>>[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([Cl:13])[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([F:16])[CH:7]=1

Participants

Reactant 3

HCID 680234-Fluorobenzaldehyde

HCID 5880883,4-Difluorobenzaldehyde

HCID 57437156Methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate

Product 1

HCID 649004543-Chloro-3-(3,4-difluoro-phenyl)-2-oxo-propionic acid methyl ester

Procedure

This compound was synthesised as 3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methyl ester but using 3,4-difluorobenzaldehyde instead 4-fluorobenzaldehyde.

Sources & evidence

ORD record: ord-fd204aa62ec449f8a5d2b611355840d3
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07994336B2

Reaction notes

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