Sodium Hydroxide → HCID 178482384, compound

HRID 1671753Notes

Reaction equation

HRID 1671753 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.[Cl:11][C:12]1[N:17]=[C:16](Cl)[N:15]=[C:14]([NH:19][CH3:20])[N:13]=1.[OH-].[Na+]>CC#N.O>[Cl:11][C:12]1[N:13]=[C:14]([NH:19][CH3:20])[N:15]=[C:16]([NH:1][C@@H:2]2[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]2)[N:17]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 3122014,6-dichloro-N-methyl-1,3,5-triazin-2-amineHCID 178511566HCID 178511566, compound

Product 1

HCID 178482384HCID 178482384, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

Commercially available cis-4-aminocyclohexanecarboxylic acid (17.46 mmol) was added to the above crude solution of 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine in CH3CN:H2O (1:1, 28.6 mL). The reaction mixture was stirred at room temperature to 40° C. for 3 hours while the pH was maintained between 9 and 10 with addition of a NaOH solution. LCMS analysis showed the complete consumption of 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine. The crude product was used in the next step. MS (ES+): m/e 286.0 [M+H]+.

Workup

  1. customthe complete consumption of 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine

Sources & evidence

ORD record
ord-c480f1e1473649bda25571629f245148
Source dataset
uspto-grants-2011_08
Patent number
US07994317B2

Reaction notes

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