Sodium Hydroxide → HCID 178482384, compound

Participants

Reaction Steps

Commercially available cis-4-aminocyclohexanecarboxylic acid (17.46 mmol) was added to the above crude solution of 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine in CH3CN:H2O (1:1, 28.6 mL). The reaction mixture was stirred at room temperature to 40° C. for 3 hours while the pH was maintained between 9 and 10 with addition of a NaOH solution. LCMS analysis showed the complete consumption of 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine. The crude product was used in the next step. MS (ES+): m/e 286.0 [M+H]+.

Provenance & Evidence